| 国产吗氯贝胺与阿米替林治疗抑郁症双盲和开放试验 |
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| 引用本文： | 刘小林,陈红菊,刘晓萍,周新芳,李文学,张勇,谭雯峰.国产吗氯贝胺与阿米替林治疗抑郁症双盲和开放试验[J].中国民康医学,2001,13(4):207-210. |
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| 作者姓名： | 刘小林 陈红菊 刘晓萍 周新芳 李文学 张勇 谭雯峰 |
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| 作者单位： | 430022,武汉市精神病医院 |
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| 摘 要： | 目的评价国产吗氯贝胺的抗抑郁疗效和不良反应.方法用国产吗氯贝胺(MCL)和阿米替林(AML)进行随机双盲双模拟对照观察50例,MCL开放观察15例.采用汉密顿抑郁量表(HAMD)、汉密顿焦虑量表(HAMA),副反应量表(TESS)、临床总体印象量表(CGI)评定疗效和不良反应,并定期检查肝、肾功能、心电图、脑电图、血生化(Glu、K、Na、Cl)、血压等.结果经8周观察,发现MCL抗抑郁疗效与AML相当,三组显效率分别为76%、80%、80%(P＞0.05).不良反应MCL明显较AML为少(P＜0.01),且对血压和肝肾功能等也无明显影响.结论研究结果支持MCL是一种有效且安全性高的新一代抗抑郁药.
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| 关 键 词： | 吗氯贝胺 阿米替林 抑郁症 |
| 修稿时间： | 2001年5月10日 |
Double blind and open trial on treating depression with Moclobemicle and Amitriptyline. |
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| LIU Xiaolin,CHEN Hongju,LIU Xiaoping,et al..Double blind and open trial on treating depression with Moclobemicle and Amitriptyline.[J].medical journal of chinese peoples health,2001,13(4):207-210. |
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| Authors: | LIU Xiaolin CHEN Hongju LIU Xiaoping |
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| Institution: | LIU Xiaolin,CHEN Hongju,LIU Xiaoping,et al.Mental Hospital in Wuhan city,430022,China |
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| Abstract: | Objectives:To study the efficacy and side effects of MCL on treating depression.Methods:50 depressive patients divided randomly into MCL and AML groups and 15 cases of MCL group adapted open observation.We measured the efficacy and side effect with HAMD,HAMA,TESS,CGI and tested kidney function,liver function,EET,ECT,biochemical analysis and so on.Results:The efficacy had no difference between MCL and AML by 8\|week observation.The effective rate of three groups were separately 76%,80%,80%( P >0.05)The side\|effects of MCL group was lower than that of AML group ( P <0.01).MCL had no change on kidney function and blood pressure.Conclusion:The study proved that MCL was a effective antidepressant. |
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| Keywords: | MCL AML Depression |
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