柴胡疏肝散加减治疗经前期综合征35例疗效观察

目的：观察柴胡疏肝散治疗经前期综合征的疗效。方法：将70例经前期综合征患者随机分为2组各35例,治疗组以柴胡疏肝散加减方治疗,对照组以多虑平、谷维素治疗。疗效采用汉密顿焦虑量表（HAMA）、焦虑自评量表（SAS）、抑郁自评量表（SDS）,不良反应和安全性用不良反应量表（TESS）评定和实验室检查。结果：治疗组总有效率为88%,对照组总有效率为60.0%,2组疗效比较,有极显著性差异（P〈0.01）。在4周末和8周末,HAMA评分2组均有显著下降,且治疗组对照组同期比较,均有显著性差异和极显著性差异（P〈0.05、P〈0.01）;2组治疗后SAS、SDS评分均显著减少,治疗前后比较,有极显著性差异（P〈0.01）。结论：柴胡疏肝散加减治疗经前期综合征效果优于多虑平。

Clinical Observation of Modified Chaihu Shugan Powder for 35 Cases of Premenstrual Syndrome

Objective：To observe therapeutic effects of Chaihu Shugan powder on premenstrual syndrome.Methods：Seventy patients were randomly divided to treatment group（n=35） and control group（n=35）,respectively treated with modified Chaihu Shugan powder,or doxepin,oryzanol. The clinical effect and side effect were assessed with HAMA,SAS,SDS and TESS,as well as laboratory examination.Results：The effective rate of research group and control group were respectively 88% and 60% （P〈0.01）. After 4 and 8 weeks of treatment,HAMA scores of both groups significantly dropped with significant differences between them （P〈0.05,P〈0.01）. After treatment SAS and SDS scores of both groups were significantly decreased when compared with the scores before treatment （P〈0.01）. The difference was significant between the two groups （P〈0.01）. Conclusion：Modified Chaihu Shugan powder has better effects on premenstrual syndrome than doxepin.