| 肉毒杆菌毒素局部注射联合小气囊扩张治疗贲门失弛缓症 |
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| 引用本文： | 徐恩斌,白厚喜,蔡永国,黄宗文,熊冶红,张忠兵.肉毒杆菌毒素局部注射联合小气囊扩张治疗贲门失弛缓症[J].实用临床医学(江西),2007,8(5):14-15,18. |
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| 作者姓名： | 徐恩斌 白厚喜 蔡永国 黄宗文 熊冶红 张忠兵 |
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| 作者单位： | [1]中国人民解放军第四〇四中心医院消化科,山东威海264200 [2]上海市长征医院消化科,上海200003 |
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| 摘 要： | 目的：探讨肉毒杆菌毒素（BT）联合小气囊扩张治疗贲门失弛缓症的疗效及食管动力学变化.方法：29例贲门失弛缓症患者, 在内镜直视下行食管下部括约肌（LES）内注射 BT联合小气囊扩张治疗,进行症状评分及食管测压检查.结果：29例患者临床症状较治疗前明显改善（P＜0.05）;食管下部括约肌压力（LESP）,松弛率（LESRR）明显降低（P＜0.01）;治疗前后食管体部均为非推进性蠕动波.结论：经内镜注射BT联合小气囊扩张治疗贲门失弛缓症可明显缓解患者的临床症状,改善食管动力,是一种简单、安全、有效的治疗方法.
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| 关 键 词： | 贲门失弛缓症 肉毒杆菌毒素 内镜球囊扩张 |
| 文章编号： | 1009-8194（2007）05-0014-02 |
| 修稿时间： | 2007-02-02 |
Study on Intrasphincteric Injection of Botulinum Toxin Combined with Small Balloon Dilation |
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| XU En-bin,BAI Hou-xi,CAI Yong-guo,HUANG Zong-wen,XIONG Ye-hong,ZHANG Zhong-bing.Study on Intrasphincteric Injection of Botulinum Toxin Combined with Small Balloon Dilation[J].Practical Clinical Medicine,2007,8(5):14-15,18. |
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| Authors: | XU En-bin BAI Hou-xi CAI Yong-guo HUANG Zong-wen XIONG Ye-hong ZHANG Zhong-bing |
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| Institution: | 1. Department of Gastroenterology, the 404th Hospital of PLA ,Weihai 264200, China ; 2. Department of Gastroenterology ,Changzheng Hospital, Shanghai 200003, China |
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| Abstract: | Objective:To study the effectiveness of intrasphincteric injection of botulinum toxin and small balloon dilation on the patients with esophageal achalasia and the changes of esophageal dynamics in them.Methods:Twenty-nine patients were treated with intrasphincteric injection of botulinum toxin and small balloon dilation.The clinical scores and manometry were compared.Results: After combine treatment,the clinical symptoms were significantly improved(P<0.05),and LESP and LESRR were lower than those before(P<0.01).The motor patterns of esophageal body were not propgating before or after treatment.Conclusion: The combination of intrasphincteric injection of botulinum toxin and small balloon dilation is an effective procedure with the advantages of lasting longer time,less complications and milder chest pain. |
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| Keywords: | achalasia botulinum balloon dilation |
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