柏连草根冲剂药效学研究

目的:研究柏连草根冲剂的解热、镇痛和抗炎作用。方法:用蛋白胨制备兔发热模型法研究其解热作用;用扭体法和热板法观察其镇痛作用;用角叉菜胶致大鼠足跖肿胀法和二甲苯致小鼠耳肿胀法研究其抗炎作用。结果:柏连草根冲剂能显著抑制蛋白胨所致体温升高;能明显减少小鼠的扭体次数,并显著延长小鼠的痛觉反应时间;能明显减轻小鼠耳肿胀及大鼠足跖肿胀反应。结论:柏连草根冲剂具有解热、镇痛和抗炎作用。

Experimental study of Bailian Caogen granule on pharmacodynamics

Objective: To study the analgesic,antipyretic and anti-inflammatory effect of Bailian Caogen granule.Method: The antipyretic effects of Bailian Caogen granule was evaluated in rabbit fever model induced by peptone.The analgesic effect of the drug was studied with pain model of mice induced by acetic acid and hot plate,The severity of oedema in inflamed animal was observed to study the anti-inflammatory effects of Bailian Caogen granule.Result:Bailian Caogen granule could obviously inhibit the fever of rabbits.The number of writhing induced by acetic acid was reduced and the pain threshold of mice was increased by Bailian Caogen granule.Bailian Caogen granule also had anti-inflammatory activity against xylene-induced mouse ear swelling and carrageenin-induced rat paw edema.Conclusion: Bailian Caogen granule has significant analgesic,antipyretic and anti-inflammatory activities.