精神分裂症患者神经内分泌激发试验对照研究

目的：以帕罗西汀为探针探讨首发精神分裂症的中枢5-羟色胺(5-HT)系统的功能。方法：患者组为首发精神分裂症患者24例；另选择年龄、性别相匹配的15名正常人为对照组。口服40mg帕罗西汀作为激发剂，每隔1．5h连续抽取静脉血，共5次。使用酶联免疫吸附法测定血浆皮质醇及催乳素浓度。结果：试验前患者组血浆基础催乳素及皮质醇浓度显著高于对照组，激发试验后患者组2种激素浓度显著高于基础值及对照组；而帕罗西汀对正常人催乳素、皮质醇的释放增加不明显。结论：首发精神分裂症患者中枢5-HT功能可能亢进。

A control study on paroxetine induced neuroendocrine challenge test in schizophrenics

Objective:To study the central serotonergic function of first episode,non-medicated schizophrenics. Method:A paroxetine induced cortisol and prolactin response test was conducted in 24 inpatients with diagnosis of first episode,non-medicated schizophrenia.15 matched normal individuals were recruited as controls. Results:There was a significant increase in the baseline plasma cortisol and prolactin level in the patient group compared with the controls.Prolactin,cortisol responses to paroxetine in patients were significantly higher than in normal controls and the baseline.Prolactin and cortisol hormone responses to paroxetine showed no statistical difference in normal controls. Conclusion:The results suggest that central serotonergic hyperactivity occurs in first episode,non-medicated schizophrenics.