葡萄球菌性烫伤样皮肤综合征35例临床分析

目的：分析葡萄球菌性烫伤样皮肤综合征（staphylococcal scalded skin syndrome，SSSS）的发病年龄、诱发因素、临床表现、实验室检查、治疗及预后。方法：回顾性分析35例儿童金葡菌烫伤样皮肤综合征的临床资料。结果：35例病例中，有21例发生于3岁以内婴幼儿，约占总病例的60％；发病中位年龄为2岁5个月；皮损主要表现为触痛性红斑、松弛性大疱、表皮剥脱（100％），口周放射状皲裂（94．3％），发热（42．9％），结膜炎（37．1％），实验室检查血白细胞及c反应蛋白未见显著性升高。结论：SSSS近年来时有发生，婴幼儿触痛性红斑、松弛性大疱、表皮剥脱伴口周放射状裂纹时应高度怀疑本病。早期、足量、有效的使用抗生素，是治疗的关键，联合大剂量静脉注射免疫球蛋白，可明显缩短病程。

Clinical analysis of 35 patients with staphylococcal scalded skin syndrome

Objective:To describe the causative factor, onset age, clinical manifestation, laboratory examination and therapy of 35 cases of staphylococcal scalded skin syndrome (SSSS). Methods:We present an observational cohort study. We review the cases of staphylococcal scalded skin syndrome monitored at in patient department during the last ten years (January 1998 to December 2007).Results:We obtained 35 patients, 21 cases (60%) occurred during in the first 3 years. The mean age at diagnosis was 29 months. Main cli...