| 舒林酸对实验性高钙尿症的防治作用 |
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| 引用本文： | 赵东宝,崔若兰,袁伟杰. 舒林酸对实验性高钙尿症的防治作用[J]. 肾脏病与透析肾移植杂志, 1999, 11(4): 327-329 |
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| 作者姓名： | 赵东宝 崔若兰 袁伟杰 |
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| 作者单位： | 第二军医大学长海医院肾内科,上海,200433 |
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| 摘 要： | 目的 观察新型非类固醇类抗炎药－舒林酸对实验性高钙尿症的防治作用，探讨其可能机制。方法 建立大鼠实验性高钙尿症模型，观察舒林酸治疗后２周和４周尿Ｇａ、尿Ｃａ／Ｃｒ、尿ＮＡＧ／Ｃｒ以及肾和十二指肠Ｃａ＾２＋ＡＴＰ酶（钙泵）的变化。结果 ２周和４周时尿Ｃａ、尿Ｃａ／Ｃｒ、尿ＮＡＧ／Ｃｒ及肾和十二指肠Ｃａ＾２＋ＡＴＰ酶均显著下降（Ｐ〈０．０１），２４ｈ尿钙定量与尿ＡＮＧ／Ｃｒ值呈正相关（Ｐ〈０．０１）。
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| 关 键 词： | 高钙尿症 钙泵 舒林酸 药物疗法 |
THERAPEUTIC EFFECTS AND ITS RELATED MECHANISM OF SULINDAC ON EXPERIMENTAL HYPERCALCIURIA |
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| Zhao Donbao,Cui Ruolan,Yuan Weijie. THERAPEUTIC EFFECTS AND ITS RELATED MECHANISM OF SULINDAC ON EXPERIMENTAL HYPERCALCIURIA[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 1999, 11(4): 327-329 |
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| Authors: | Zhao Donbao Cui Ruolan Yuan Weijie |
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| Abstract: | OBJECTIVE To observe the therapeutic effects of sulindac(a new type of NSAIDs)on experimental hypercalciuria and to clarify its pharmacological mechanism. METHODOLOGY The urine calcium creatinine ratio(Ca/Cr),24 hour quantitative urinary calcium(UCa),N acetyl beta D glucosaminidase creatinine ratio(NAG/Cr)and activity of Ca 2 ATPase in both kidney and duodenum were measured after 2 and 4 weeks treatment with sulindac in rat models of hypercalciuria established by injection of vitamin D3. RESULTS Ca/Cr,Uca,NAG/Cr and Ca 2 ATPase of target tissues were significantly decreased in rats treated with sulindac as compared to rats injected with vitamin D3.A significant positive relationship was found beween UCa and NAG/Cr. CONCLUSION Sulindac displays a remarkable anti calciuric action through down regulating Ca 2 ATPase in the target tissue. |
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| Keywords: | hypercalciuria calcium pomp sulindac |
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