Virtual topological optimisation of scaffolds for rapid prototyping |
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| Authors: | Henrique de Amorim Almeida Paulo Jorge da Silva Bártolo |
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| Affiliation: | 1. Department of Biomedical Engineering, Duke University, United States;2. Department of Mechanical Engineering and Materials Science, Duke University, United States;3. Institut für Werkstoffkunde (Materials Science), Leibniz Universität Hannover, Germany;4. School of Materials Science and Engineering, Georgia Institute of Technology, United States;5. Knight Campus for Accelerating Scientific Impact, University of Oregon, United States;1. IDMEC, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisboa, Portugal;2. Scaffold Tissue Engineering Group, University of Michigan, 3412 GGB, 2350 Hayward, Ann Arbor, MI 48109-2125, USA;1. Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210, USA;2. School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA;1. RMIT Centre for Additive Manufacturing, School of Aerospace, Mechanical and Manufacturing Engineering, RMIT University, Melbourne, Australia;2. Department of Mechanical Engineering, Politecnico di Milano, Milan, Italy;1. State IJR Center of Aerospace Design and Additive Manufacturing, Northwestern Polytechnical University, Xian, Shaanxi 710072, China;2. INRA, UR1268 Biopolymères Interactions Assemblages, Nantes F-44300, France;3. LUNAM University of Nantes Angers Le Mans, CNRS, GEPEA, UMR 6144, IUT de Nantes, 2 avenue du Professeur Jean Rouxel, 44475 Carquefou Cedex, France |
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| Abstract: | Advanced additive techniques are now being developed to fabricate scaffolds with controlled architecture for tissue engineering. These techniques combine computer-aided design (CAD) with computer-aided manufacturing (CAM) tools to produce three-dimensional structures layer by layer in a multitude of materials. Actual prediction of the effective mechanical properties of scaffolds produced by additive technologies, is very important for tissue engineering applications. A novel computer based technique for scaffold design is topological optimisation. Topological optimisation is a form of “shape” optimisation, usually referred to as “layout” optimisation. The goal of topological optimisation is to find the best use of material for a body that is subjected to either a single load or a multiple load distribution. This paper proposes a topological optimisation scheme in order to obtain the ideal topological architectures of scaffolds, maximising its mechanical behaviour. |
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