Involvement of Substance P and the Neurokinin-1 Receptor in Radiation-Induced Hair Loss in Mice |
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| Authors: | Kouichi Yamamoto Naoko Kureyama Keiko Asano Toshiji Ikeda Atsushi Yamatodani |
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| Affiliation: | 1. Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan;2. Department of Accelerator Science, The Institute of Scientific and Industrial Research, Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan |
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| Abstract: | We investigated the involvement of substance P (SP) and the neurokinin-1 receptor (NK1 R) in the development of radiation-induced hair loss in mice. A dose of 40 Gy of gamma irradiation induced hair loss from the 10th to at least the 60th day after irradiation. A specific NK1R antagonist, CP-99,994, significantly delayed radiation-induced hair loss and reduced its severity. Furthermore, gamma irradiation induced the expression of preprotachykinin-A, a precursor protein of SP, mRNA in irradiated murine skin on the 10th and 30th days after irradiation. These results indicated that gamma irradiation-induced hair loss was mediated by SP via NK1R. |
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| Keywords: | radiation-induced hair loss substance P neurokinin-1 receptor |
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