脑血管源性细胞间通讯异常与脑疾病机制研究

以脑卒中、阿尔茨海默病、癫痫等为主要代表的脑部疾病一直是危害人类健康的世界性难题,加重社会医疗负担。近年来,脑内神经血管单元不同类型细胞组分(脑血管内皮细胞、小胶质细胞、星形胶质细胞和神经元细胞)的联系与脑疾病之间的关系也越来越受到重视。在不同脑部疾病发生、发展及转归病理过程中,它们结构本身和通讯耦联功能产生着相应的变化。该综述在总结前人对细胞间通讯异常以及其与脑部疾病发作机制的相关研究的基础上,对其分子机制进行论述,以期找到治疗神经精神疾病的新靶点或新方法。

Research on mechanism of abnormalcerebrovascular cell communication and brain diseases

Brain diseases such as stroke,Alzheimer′s disease,epilepsy,have always been worldwide problems that endanger human health and are costly disease from societal perspectives.In recent years,more and more attention has been paid to the relationship between components of neurovascular unit(cerebrovascular endothelial cell,microglia,astrocyte and neuron)and brain diseases.Not only have their structures changed during the pathological process,but also coupling communication and functions have changed accordingly.On the basis of summarizing previous studies on the abnormalities in intercellular communication and its mechanism with brain disorders,this review is expected to find novel targets or therapeutic treatment for neuropsychiatric diseases.