Role of Two-component System of Streptococcus mutans in the Adaptive Response to the Oral Environment |
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| Authors: | Miki Matsuo Hitoshi Komatsuzawa |
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| Institution: | 1. Department of Biological Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;2. Industrial Products Safety Center of Tianjin Entry-Exit Inspection and Quarantine Bureau, China;1. Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Key Laboratory of Fishery Drug Development, Ministry of Agriculture, Key Laboratory of Aquatic Animal Immune Technology, Guangzhou 510380, Guangdong China;2. Liaoning Animal Medical Research Institute, Shenyang, 110164, China;3. FLI Insel Riems, Sudufer 10, 17493 Greifswald-Insel Riems, Germany |
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| Abstract: | Biofilm is a colony-like aggregate consisting of microorganisms and polysaccharide (glycocalyx) that are produced by microorganisms and adhere to solid surfaces. In the oral cavity, biofilm, called dental plaque, is known as a virulence factor for dental caries. Biofilm is formed and adapts to various environmental factors in the oral cavity. Streptococcus mutans, a cariogenic bacteria, plays an important role in biofilm formation. In this study, we focused on a bacterial two-component system (TCS) as an environmental adaptation factor in S. mutans. We comprehensively evaluated the involvement of TCS in response to various factors associated with the oral cavity using 14 TCS deletion mutants of S. mutans. Furthermore, we evaluated the expression of each TCS in sucrose-dependent biofilm cells of S. mutans. Our findings suggested that multiple TCS play important roles promoting in resistance to environmental stresses and the formation of biofilm. |
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