Prevalence of pilus-encoding islets among acute otitis media Streptococcus pneumoniae isolates from Israel |
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| Authors: | M. Moschioni G. De Angelis S. Melchiorre V. Masignani E. Leibovitz M.A. Barocchi R. Dagan |
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| Affiliation: | 1. Novartis Vaccines and Diagnostics s.r.l., Research Center, Siena, Italy;2. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel;3. Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva, Israel |
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| Abstract: | We evaluated the distribution of the two known Streptococcus pneumoniae pilus encoding islets (PI-1 and PI-2) among a panel of 113 acute otitis media clinical isolates from Israel. PI-1 was present in 30.1% (n = 34) of the isolates tested, and PI-2 was present in 7% (n = 8). In addition, we found that: (i) the PI positive isolates, 50% of which belong to the international clones Spain9V-3 (ST156) and Taiwan19F-14 (ST236), correlate with the genotype (as determined by multilocus sequence typing) but not with the serotype; (ii) PI-2 was not present in the absence of Pl-1; and (iii) the frequency of PI-1 was higher among antibiotic-resistant isolates. |
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| Keywords: | Acute otitis media antibiotic resistance genotype pilus-encoding islet |
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