The House Shrew,Suncus murinus,as a Model Organism to Investigate Mammalian Basal Condition of Tooth Development |
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| Authors: | Atsushi Yamanaka Masanori Uemura |
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| Institution: | 1. Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health University, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan;2. Shared-Use Research Center, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan;3. Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan;4. Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1 Uchinada, Ishikawa 920-0293, Japan;5. Department of Occupational Pneumology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan;6. Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan;7. Laboratory of Pathology, Fukuoka Tokushukai Hospital, Fukuoka 816-0864, Japan;8. Asahi-Matsumoto Hospital, Kitakyushu 800-0242, Japan;1. University of Pittsburgh School of Medicine, Department of Pharmacology and Chemical Biology, USA;2. University of California Los Angeles, Department of Neurology, USA;3. University of Pittsburgh School of Medicine-Pittsburgh, Institute of Neurodegenerative Diseases, USA |
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| Abstract: | Mammalian dentition is characterized by regional differentiation into incisors, canines, premolars and molars in each jaw quadrant (heterodonty), and tooth replacement once during the lifetime (diphyodonty). Despite their significance in various research fields, little is known about the developmental mechanisms regulating tooth type (class) determination and diphyodont tooth replacement. The mouse, the most popular laboratory animal, is not appropriate for the investigation of heterodonty and diphyodonty, because of its highly specialized dentition. The house shrew, Suncus murinus, has been suggested to be a potentially excellent model organism to study the mammalian basal condition of tooth development. Using three-dimensional (3-D) reconstructions of dental epithelium from serial histological sections, and Sonic hedgehog (Shh) expression patterns, we have precisely located the tooth-forming regions of all tooth types in the developing jaws of the house shrew. The incisor region in the upper jaw is found to extend across the boundary between the frontonasal and maxillary processes. The molar-forming region is later added distal to the first demarcated tooth-forming regions by secondary extension of the dental lamina. Furthermore, we have elucidated the replacement pattern of the deciduous dentition by succession and addition (accession) of the permanent teeth in the house shrew. On the basis of new knowledge on tooth development in the house shrew, we discuss the developmental mechanisms regulating tooth type determination and diphyodont tooth replacement, and consider future prospects in the field. |
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