Novel aspects of corneal angiogenic and lymphangiogenic privilege |
| |
| Authors: | David Ellenberg Dimitri T. Azar Joelle A. Hallak Faisal Tobaigy Kyu Yeon Han Sandeep Jain Zhongjun Zhou Jin-Hong Chang |
| |
| Affiliation: | 1. Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA;2. Department of Ophthalmology, Harvard Medical School, Boston, MA, USA;3. Department of Biochemistry, The University of Hong Kong, Hong Kong;1. Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA;2. Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA;1. Department of Ophthalmology, University of Cologne, Cologne, Germany;2. Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan;1. Department of Ophthalmology, University of Cologne, Cologne, Germany;2. Cologne Ophthalmological Reading and Image Analysis Center (CORIC), University of Cologne, Cologne, Germany;1. Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, United Kingdom;2. St. Paul''s Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom;3. Department of Ophthalmology, Medical University of Innsbruck, Innsbruck, Austria;4. Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland, United Kingdom |
| |
| Abstract: | In this article, we provide the results of experimental studies demonstrating that corneal avascularity is an active process involving the production of anti-angiogenic factors, which counterbalance the pro-angiogenic/lymphangiogenic factors that are upregulated during wound healing. We also summarize pertinent published reports regarding corneal neovascularization (NV), corneal lymphangiogenesis and corneal angiogenic/lymphangiogenic privilege. We outline the clinical causes of corneal NV, and discuss the angiogenic proteins (VEGF and bFGF) and angiogenesis regulatory proteins. We also describe the role of matrix metalloproteinases MMP-2, -7, and MT1-MMP, anti-angiogenic factors, and lymphangiogenic regulatory proteins during corneal wound healing. Established and potential new therapies for the treatment of corneal neovascularization are also discussed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
