Primary investigation of 31 infants with suspected congenital rubella syndrome in Sudan |
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| Authors: | O Adam A El Hussein A El Eragi L Jin |
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| Institution: | 1. Commission for Biotechnology and Genetic Engineering - National Centre for Research - Ministry of Science and Technology;2. Central Laboratory - Ministry of Science and Technology;3. Central Veterinary Research Laboratories, Khartoum, Sudan;4. Virus Reference Department, Centre for Infections, Health Protection Agency, London, UK |
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| Abstract: | Between 2005 and 2006, clinical specimens were collected from 31 infants with suspected congenital rubella syndrome (CRS) who presented at six hospitals in Khartoum, Sudan. Eleven (35.5%) were laboratory confirmed as CRS cases by testing for anti-rubella IgM, IgG and viral genome. For the first time in Sudan, the rubella virus genome was directly detected in clinical specimens of six CRS cases and two viruses were isolated in cell culture. Phylogenetic analysis suggested that three genotypes of rubella virus (RV; 1E, 2B and 1G) were co-circulating in Sudan. The study introduced the methodology for CRS confirmation and surveillance in Sudan and provides preliminary data. |
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| Keywords: | Congenital rubella syndrome genotyping rubella virus Sudan virus isolation |
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