| 5-氨基-2,4,6-三碘异酞酸的合成 |
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| 引用本文： | 王飞镝,崔英德,邓旭忠,邱清华,宋晓锐,方岩雄.5-氨基-2,4,6-三碘异酞酸的合成[J].中国现代应用药学,2002,19(3):214-215. |
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| 作者姓名： | 王飞镝 崔英德 邓旭忠 邱清华 宋晓锐 方岩雄 |
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| 作者单位： | 1. 广州,510090,广东工业大学轻工化工学院
2. 广州,510640,华南理工大学材料学院 |
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| 摘 要： | 目的：合成非离子含碘造影剂的中间体5－氨基－2，4，6－三碘异酞酸。方法：以间苯二酸为原料，经硝化、还原与碘化，合成5－氨基－2，4，6－三磷异酞酸。结果：每步均经改进，总收率达50.2%，所得产品熔点、IR、^1HNMR、^13CNMR光谱数据，与文献报道一致。结论：本工艺路线方法简单，原料易得，易工业化生产。
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| 关 键 词： | 5－氨基－2 4 6－三碘异酞酸 合成 造影剂 药物中间体 |
Study of Synthesizing 5-Amino-2,4,6-Triiodoisophthalic Acid |
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| Wang Feidi.Study of Synthesizing 5-Amino-2,4,6-Triiodoisophthalic Acid[J].The Chinese Journal of Modern Applied Pharmacy,2002,19(3):214-215. |
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| Authors: | Wang Feidi |
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| Institution: | Wang Feidi (Wang FD,Cui Yingde (Cui YD,Deng Xuzhong (Deng XZ,Qiu Qing-hua~,Song Xiaorui (Song XR,Fang Yanxiong (Fang YX |
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| Abstract: | OBJECTIVE:To synthesize 5 amino 2,4,6 triiodoisophthalic acid, the intermedia of nonionic iodinated X ray contrast agents. METHOD:With the isopthalic as the starting material, 5 Amino 2,4,6 triiodoisophthalic acid was synthesized from isophthalic acid by a three step procedure, nitration, reduction and iodination.RESULTS:Each step was modified and improved. The overall yeilds was 50.2%. The melting point and IR? 1HNMR? 13 CNMR of the product prepared were identical to that of the reported one.CONCLUSION:The process can be easily controlled and is suitable for a scale production. |
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| Keywords: | amino 2 4 6 triiodoisophthalic acid contrast agent preparation |
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