| 钠/碘同向转运体与放射性碘治疗 |
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| 引用本文： | 陈立波. 钠/碘同向转运体与放射性碘治疗[J]. 国际放射医学核医学杂志, 2001, 25(6): 258-261 |
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| 作者姓名： | 陈立波 |
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| 作者单位： | 200233 上海, 上海市第六人民医院核医学科 |
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| 摘 要： | 钠/碘同向转运体(NIS)是一种调节甲状腺及其他组织碘转运活性的膜蛋白。NIS在甲状腺的病理生理中发挥着关键性作用,它实现了甲状腺组织摄取碘并进行甲状腺激素的生物合成,实现了甲状腺功能亢进和分化型甲状腺癌的显像诊断和放射性碘治疗。近年来,对NIS的进一步分子学研究表明,NIS有可能对甲状腺及非甲状腺肿瘤的诊断和放射性碘治疗产生更加深远的影响。
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| 关 键 词： | 钠/碘同向转运体 放射性碘治疗 甲状腺癌 乳腺癌 前列腺癌 |
| 文章编号： | 1001-098X(2001)06-0258-04 |
| 收稿时间： | 2001-10-25 |
| 修稿时间： | 2001-10-25 |
The sodium/iodide symporter and radioiodide therapy |
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| CHEN Li-bo. The sodium/iodide symporter and radioiodide therapy[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2001, 25(6): 258-261 |
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| Authors: | CHEN Li-bo |
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| Affiliation: | Nuclear Medicine Department of Shanghai Sixth People's Hospital, Shanghai 200233, China |
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| Abstract: | The sodium/iodide symporter (NIS) is an intrinsic membrane protein that mediates the active transport of iodide into the thyroid and other tissues. NIS plays key roles in thyroid pathophysiology as the route by which iodide reaches the gland for thyroid hormone biosynthesis and as a means for diagnostic scintigraphic imaging and for radioiodide therapy in hyperthyroidism and thyoid cancer. The continued molecular analysis of NIS clearly holds the potential of an even greater impact on the diagnosis and radioiodide treatment of cancer, both in thyroid and beyond. |
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| Keywords: | sodium/iodide sympertor radioiodide therapy thyroid cancer breast cancer prostate cancer |
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