沉默信息调节因子 1 与急性肺损伤/急性呼吸窘迫综合征 |
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引用本文: | 岳阳,许天祥,代琴,吕红旭,王晓霞.沉默信息调节因子 1 与急性肺损伤/急性呼吸窘迫综合征[J].中国工业医学杂志,2024,37(2):177-182. |
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作者姓名: | 岳阳 许天祥 代琴 吕红旭 王晓霞 |
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作者单位: | 1.内蒙古医科大学内蒙古临床医学院,内蒙古 呼和浩特 010110;2.内蒙古自治区人民医院肿瘤中心腹部肿瘤外科;3.内蒙古科技大学包头医学院;4.内蒙古自治区人民医院重症医学科 |
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基金项目: | 内蒙古自治区自然科学基金(2023MS08019,2018LH08002);内蒙古自治区健康科技计划项目(202201011);内蒙古自治区人民医院院内基金(2020YN06);内蒙古医科大学联合项目(YKD2022LH015) |
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摘 要: | 沉默信息调节因子1(Sirtuin1,silent information regulator 1,SIRT1)是与酿酒酵母沉默信息调节器2(Sir2)同源的去乙酰化酶家族。SIRT1通过介导多条细胞信号通路,在细胞生物学功能和疾病发生机制中发挥关键作用,调节各种疾病的病理进展。在急性肺损伤(acute lung injury,ALI)/急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)的动物模型中,SIRT1表达异常,且表达水平与模型的疾病严重程度密切相关,可能成为早期诊治ALI/ARDS新的生物学指标。本文简要综述了SIRT1通过抗炎、抗氧化应激、调节细胞凋亡及自噬、改变血管内皮细胞通透性等途径发挥其减轻ALI/ARDS的作用,探讨SIRT1在ALI/ARDS防治中的潜在价值。
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关 键 词: | 沉默信息调节因子1(SIRT1) 生物学功能 急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS) |
Sirtuin1 and acute lung injury/acute respiratory distress syndrome |
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Institution: | Inner Mongolia Clinical Medical College,Inner Mongolia Medical University,Hohhot, Inner Mongolia 010110,China |
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Abstract: | Sirtuin1 (silent information regulator 1, SIRT1) is a family of deacetylases homologous to silent information regulator 2 (Sir2) in Saccharomyces cerevisiae.SIRT1 plays a crucial role in cellular biological function and disease pathogene-sis by mediating multiple cellular signaling pathways,regulating pathological progression of various diseases.In animal models of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS),SIRT1 show abnormal expression and the expression level is closely related to the severity of the disease in the model,therefore, it is expected to become a new emerging biological indicator for early diagnosis and treatment of ALI/ARDS.This article briefly reviews the role of SIRT1 in reducing ALI/ARDS through anti-inflammatory, antioxidant stress,regulating cell apoptosis and autophage, and altering endothelial cell permeability,and the potential value of SIRT1 in the prevention and treatment of ALI/ARDS is explored as well. |
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Keywords: | Sirtuin1 (silent information regulator 1 SIRT1) biological function acute lung injury (ALI)/acute respir-tatory distress syndrome (ARDS) |
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