FcRn: the MHC class I-related receptor that is more than an IgG transporter |
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| Affiliation: | 1. Université Paris Descartes, Faculté de Médecine, Service de Médecine Interne, Centre de Référence Pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France;2. Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France;3. CHRU de Tours, Laboratoire d''Immunologie, France;4. Université François-Rabelais de Tours, France;5. CNRS, UMR 7292, Tours, France |
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| Abstract: | Recent data have indicated that the major histocompatibility complex (MHC) class I-related receptor FcRn plays a role in regulating serum IgG levels, in addition to transferring maternal IgGs across the rodent neonatal gut. The isolation of a human homolog of FcRn from placenta suggests that the studies in rodents have relevance to understanding similar processes in humans. This has implications for the engineering of improved antibodies for therapy. |
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