Cellular environments and apoptosis: tissue microenvironments control activated T-cell death |
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| Institution: | 1. Department of Climatology and Atmosphere Protection, Institute of Geography and Regional Development, University of Wrocław, Kosiby 8, 51-621 Wrocław, Poland;2. Department of Climatology, Institute of Physical Geography and Environmental Planning, Adam Mickiewicz University, Bogumiła Krygowskiego 10, 61-680 Poznań, Poland;3. Skywarn Poland, Warsaw, Poland |
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| Abstract: | Activated T cells must he removed by apoptosis at the end of an immune response in order to maintain cellular homeostasis. Although recent attention has focused on the rule of CD95 (Fas/APO-1) in the elimination of activated T cells, apoptosis can also be induced by cytokine deprivation. Here, Arne Akbar and Mike Salmon describe how both death pathways interact in activated T cells and are profoundly influenced by different tissue microenvironments. |
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