Use of enteric polymers for production of microspheres by extrusion-spheronization |
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| Institution: | 1. College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China;2. Key Laboratory of Environment Biology and Pollution Control, Hunan University, Ministry of Education, Changsha 410082, PR China;3. Collaborative Innovation Center of Resource–Conserving & Environment-friendly Society and Ecological Civilization, Changsha 410083, PR China;4. College of Environment and Energy, South China University of Technology, Guangzhou 510006, PR China |
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| Abstract: | To simplify the manufacture of enteric dosage forms, incorporation of enteric polymers into the matrix of phenylbutazone microspheres produced by extrusion-spheronization was compared to the coating of cores. The effect of different polymers, cellulose acetate phthalate (CAP), hydroxypropylmethyl cellulose phthalate (HPMCP) and Eudragit L100-55 and the amount of granulating liquid were evaluated for the effect of selected physical properties and drug release behavior. Using the enteric polymers in the microsphere cores showed a similar pattern of release to the coated spheres with no notable difference in drug release behavior being observed between the dosage forms. The microspheres with Eudragit L100-55 in the matrix were less friable and disintegration times were much closer to the coated microspheres than formulations including the other polymers. Variation of the amount of Eudragit L100-55 in the cores allowed optimization of disintegration and drug release profiles. |
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