IL-6 and APPs: anti-inflammatory and immunosuppressive mediators |
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| Affiliation: | 1. Department of Nuclear Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, China;2. Department of Nursing, Medical College, Jinan University, Guangzhou, China;1. Uberlândia Federal University, Biomedical Science Institute, Department of Morphology, Uberlândia, Brazil;2. Uberlândia Federal University, School of Dentistry, Uberlândia, Brazil;3. São Paulo University, School of Medicine, São Paulo, Brazil;4. Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, CA, USA |
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| Abstract: | Acute inflammation is accompanied by changes in the concentrations of acute phase proteins (APPs), While much is known about the cytokines involved in the initiation of inflammation, less is known about the mediators involved in its resolution. Recent data suggest that interleukin 6 (IL-6) and IL-6-regulated APPs are anti-inflammatory and immuno-suppressive, and may negatively regulate the acute phase response. |
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