Tumour cell kinetics as prognostic factor in surgically-treated-non-small cell lung cancer |
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| Institution: | 1. Laboratory of Radiation Biology, Centre of Oncology, Garncarska 11, 31-115 Kraków, Poland;2. Department of Oncological Surgery, Centre of Oncology, Garncarska 11, 31-115 Kraków, Poland;1. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China;2. Department of Chemistry, Lanzhou University, Lanzhou 730000, China;3. Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou 730000, China;4. Key Laboratory of Sensor and Sensor Technology of Gansu Province, Lanzhou 730000, China;5. Institute of Sensor Technology, Gansu Academy of Sciences, Lanzhou 730000, China;1. Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, China;2. School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China;3. Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou 510275, China;1. Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, China West Normal University, Nanchong 637002, China;2. Institute of Applied Chemistry, China West Normal University, Nanchong 637002, China;3. School of Basic Medical Sciences, North Sichuan Medical College, Nanchong 637000, China |
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| Abstract: | The proliferative rate of tumour cells were studied in 80 non-small cell lung cancers (NSCLC) treated surgically at the Centre of Oncology in Kraków, between 1990 and 1996. There were 56 squamous cell carcinoma (SqLC) and 24 non-SqLC (18 adenocarcinoma (AcLC), three large cell carcinomas (LcLC), three mixed tumours). The proliferative potential of the tumour cells was studied on the basis of percentage of cells in the S-phase (S-phase fraction, SPF), proliferative index (PI, number of cells in S+ G2/M phases), bromodeoxyuridine labelling index (BrdUrdLI), and predictive potential doubling time (pred Tpot). Significant differences in the proliferating rate between histological groups of tumours were shown by the BrdUrdLI. The 5-year survival time for patients with higher proliferating tumours (BrdUrdLI>4.1%, optimal cutoff level) was significantly higher (median survival time of >60 months) than those with lower proliferative potential (BrdUrdLI ≤4.1%) (median survival time of 19 months, P=0.0091). SqLC patients had significantly better 5-year survival (median survival time of 47.5 months) than those with non-SqLC (median survival time of 18.5 months). Cox multivariate analysis showed that only higher proliferation of the tumour cells (BrdUrdLI >4.1%), and lower clinical stage (I and II) were favourable prognostic factors in respect to patients' survival. |
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