腹部迷走传入冲动对杏仁核、下丘脑核团和胃的生长抑素含量的影响

使用放射免疫分析方法和微穿孔技术,观察了切断大鼠腹部迷走神经腹干和刺激其向中端对杏仁核、下丘脑和胃的生长抑素含量的影响。切断迷走神经,杏仁核生长抑素含量无明显改变,外侧视前区、下丘脑腹内侧核和室旁核的生长抑素含量下降,胃窦与胃体的粘膜和肌层的生长抑素含量也下降,表明腹部迷走神经冲动对下丘脑和胃的生长抑素有紧张性影响。刺激腹部迷走神经向中端,杏仁的内侧核、外侧核和中央核的生长抑素含量减少,外侧视前区、下丘脑腹内侧核和室旁核的生长抑素含量增加,胃窦部粘膜和肌层的生长抑素含量也增加,提示了杏仁核和下丘脑一些核团的生长抑素可能在内脏传入信息的中枢整合活动中起作用。

EFFECTS OF ABDOMINAL VAGAL AFFERENTS ON THE SOMATOSTATIN CONCENTRATION IN AMYGDALA, HYPOTHALAMIC NUCLEI AND STOMACH OF RATS

Effects of cutting the ventral trunk of abtominal vagus nerve of rats. and stimulating its central end on the somatostatin concentration in amygdala, hy-pothalamic nuclei and stomach were studied by radioimmunoassay.Following section of the vagus nerve, the somatostatin concentration of amygdaloid nuclei was not changed, that of lateral preoptic area, hyopthalamic ventromedial nuclei and paraventricular nuclei was reduced, and that of mucosal and muscular layers of antrum and corpus of stomach was also decreased, indicating the tonic influence of the vagus nerve impulses on hypothalamic and gastric somatostatin concentration. Electrical stimulation of the central end of the vagus nerve decreased the somatostatin concentration of medial, lateral and central amygdala, increased that of lateral preoptic area, hypothalamic ventromedial and paravcntricular nuclei, and also increased that of mucosal and muscular layers of gastric antrum, suggesting that somatostatin in amygdala and hypothalamic nuclei plays a role in central integration of visceral afferent information.