Clonal expansions of CD8+ T cells in latently HSV-1-infected human trigeminal ganglia |
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| Authors: | Kathrin Held Ingrid Eiglmeier Susanne Himmelein Inga Sinicina Thomas Brandt Diethilde Theil Klaus Dornmair Tobias Derfuss |
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| Affiliation: | Institute of Clinical Neuroimmunology, Ludwig Maximilian University, 81377 Munich, Germany. |
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| Abstract: | Herpes simplex virus type 1 latency in trigeminal ganglia (TG) is accompanied by a chronic immune cell infiltration. The aim of this study was to analyse the T-cell receptor β-chain repertoire in latently HSV-1 infected human TG. Using complementarity-determining region 3 spectratyping, 74 expanded β-chain sequences were identified in five TG. No clone appeared in more than one subject. Similar clones were present in the right and the left TG of two subjects. This indicates that these T cells are primed in the periphery and recognise the same antigen in the TG of both sides. |
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