Retrograde reperfusion via vena cava lowers the risk of initial nonfunction but increases the risk of ischemic-type biliary lesions in liver transplantation – a randomized clinical trial |
| |
Authors: | Christoph Heidenhain Michael Heise Sven Jonas Manuela Ben-Asseur Gero Puhl Jens Mittler Armin Thelen Sven Schmidt Jan Langrehr Peter Neuhaus |
| |
Institution: | Department of General, Visceral and Transplantation Surgery, Charité, Campus Virchow, Universit?tsmedizin Berlin, Berlin, Germany. christoph.heidenhain@charite.de |
| |
Abstract: | Initial nonfunction (INF) and biliary complications such as ischemic-type biliary lesion (ITBL) remain two major complications in clinical orthotopic liver transplantation (OLT). The influence of ischemia and reperfusion injury (I/R) as a significant risk factor for both complications is widely unquestioned. A new reperfusion technique that reduces I/R injury should lead to a reduction in both INF and ITBL. One hundred and thirty two OLT patients were included in this study and randomized into two groups. Group A underwent standard reperfusion with anterograde simultaneous arterial and portal reperfusion and group B received retrograde reperfusion via the vena cava before sequential anterograde reperfusion of portal vein and hepatic artery. Serum transaminase level as a surrogate parameter for I/R injury and serum bilirubin level as a parameter for graft function were significantly reduced during the first week after OLT in group B. INF rate was 7.7% in group A and 0% in group B (P = 0.058). ITBL incidence was 4.55% in group A versus 12.3% in group B (P = 0.053). Retrograde reperfusion seemed to be beneficial for hepatocytes, but was detrimental for the biliary epithelium. The unexplained increased incidence of ITBL after retrograde reperfusion will be focus of further investigation. |
| |
Keywords: | bile duct complication ischemia and reperfusion injury retransplantation |
|