乳腺癌骨转移的临床病程

目的 探讨乳腺癌骨转移的临床病程和规律。方法 回顾性分析345例乳腺癌患骨转移好发部位、病灶特点、发生时间、激素受体分布情况及预后等规律。结果 乳腺癌骨转移好发部位依次是腰椎、胸椎、骨盆、肋骨和股骨；几乎全部是溶骨性病灶；中位发生骨转移时间是术后33个月；88．7％患就诊时有相应症状；骨转移患中激素受体阳性比例较高；首发骨转移的预后介于软组织和内脏之间；延缓骨转移与内脏转移的间隔时间有利于生存期的改善。结论 对乳腺癌骨转移规律的认识有助于临床诊断和治疗。

The clinical course of bone metastases of breast cancer

Objective To study the clinical characteristics of bone metastases of breast cancer. Methods andResults In a review of the history records of 345 patients, the most common sites of bone metastases were lumber,thoracic vertebra, pelvis, rib and femur, almost all of the bone metastases tended to be osteolytic. The median time of bonemetastasis was 33 months after the surgical procedure, which ranged from 0 to 15 years. There was a higher hormonereceptor-positive proportion in patients with bone metastasis, and the prognosis of those patients was better than visceralmetastasis ones. It was benefit to improve the survival of patients to prolong the interval between bone metastasis andviscecal metastasis. Conclusion Bone metastasis of breast cancer has its unique clinical characteristics, which can directdiagnose and therapy.