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| 人类第9号染色体微卫星改变与非小细胞肺癌发生及转移的关系 | |
| 引用本文： | Zhang S,Tang B,Liang Q,Li S,He Y,Yang L. 人类第9号染色体微卫星改变与非小细胞肺癌发生及转移的关系[J]. 中国肺癌杂志, 2000, 3(5): 369-371 |
| 作者姓名： | Zhang S Tang B Liang Q Li S He Y Yang L |
| 作者单位： | 1. 河南省胸科医院分子生物学研究室,郑州,450003 2. 河南省呼吸内科医院分子生物学研究室,郑州,450003 3. 河南省胸外科医院分子生物学研究室,郑州,450003 4. 河南省中医学院生化教研室 |
| 基金项目： | 河南省科技攻关计划项目!(981 1 70 835)资助 |
| 摘 要： | 目的 探讨人类第９号染色体短臂（９ｐ）上微卫星改变与肺癌发生及转移的相关性。方法 应用聚合酶链反应（ＰＣＲ）结合微卫星银染分析方法检测３２例非小细胞肺癌（ＮＳＣＬＣ）组织中两个微卫星标志物ＩＦＮＡ和Ｄ９Ｓ１７１的改变。结果 ３２例ＮＳＣＬＣ患者中,１４例（４３．８％）出现了微卫星标志物改变。其中伴有淋巴结转移的肺癌组织微中微卫星改变检出率为６４．７％,不伴转移的肺癌组织中微卫星改变检出率为２０％, |
| 关 键 词： | 非小细胞肺癌 染色体9p 微卫星标志物 |
| 修稿时间： | 1999-11-29 |
Correlation of microsatellite alterations on chromosome 9 and oncogenesis,metastasis in NSCLC |
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| Zhang S,Tang B,Liang Q,Li S,He Y,Yang L. Correlation of microsatellite alterations on chromosome 9 and oncogenesis,metastasis in NSCLC[J]. Chinese journal of lung cancer, 2000, 3(5): 369-371 | |
| Authors: | Zhang S Tang B Liang Q Li S He Y Yang L |
| Affiliation: | Laboratory of Molecular Biology,Henan Provincial Chest Hospital,Zhengzhou,Henan 450003,P.R.China. |
| Abstract: | Objective To investigate the relationship among microsatellite alterations on chromosome 9(9p) and the oncogenesis, metastasis of nonsmall cell lung cancer (NSCLC). Methods Two microsatellite markers, IFNA and D9S171, were analyzed in 32 cases of NSCLC by polymerase chain reactionbased silverstaining assay. Results Of 32 cases of NSCLC, 14(43.8%) had microsatellite alterations. The alteration frequency was 64.7% in NSCLC with lymph node metastasis, and 20% in those without lymph node metastasis. There was significant difference between the two groups. None of benign lung tissues showed microsatellite alterations. Conclusion Microsatellite alteration on chromosome 9p in NSCLC appears to be a common and specific event, and may be a valuable molecular marker for determination of early diagnosis and metastasis of NSCLC. |
| Keywords: | Non-small cell lung cancer Chromosome 9p Microsatellite marker Polymerase chain reactio |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |