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依那普利对大鼠离体胸主动脉的舒张作用及其机制
引用本文:王丹,张轩萍,董秋菊,张明升,牛龙刚,常海良. 依那普利对大鼠离体胸主动脉的舒张作用及其机制[J]. 中国临床药理学与治疗学, 2008, 13(2): 149-153
作者姓名:王丹  张轩萍  董秋菊  张明升  牛龙刚  常海良
作者单位:1. 山西医科大学药理教研室,太原,030001,山西
2. 山西医科大学第一附属医学院心血管内科,太原,030001,山西
摘    要:目的:观察依那普利对血管的直接作用,并探讨其机制。方法:采用Powerlab生物信号采集系统记录依那普利对去甲肾上腺素(NE)和KCl预收缩的离体大鼠胸主动脉环舒张作用,观察左旋硝基精氨酸甲酯(L—NAME,10^-4mol/L)和吲哚关辛(10^-8mol/L)对其作用的影响。结果:在内皮完整的大鼠离体胸主动脉环,依那普利(10^-9~10^-4mol/L)对NE(10^-5mol/L)或KCl(20mmol/L)引起的收缩具有浓度依赖性的舒张作用。去内皮后,依那普利的舒血管作用显著减弱。在内皮完整的血管环,L—NAME(10^-4mol/L)和吲哚美辛(10^-8mol/L)对依那普利的舒血管作用具有明显的抑制作用。结论:依那普利对大鼠离体胸主动脉环具有浓度依赖性的舒张作用,此作用具有内皮依赖性,与内皮产生的NO和前列环素(PGI2)有关。

关 键 词:依那普利  胸主动脉  血管舒张  内皮  一氧化氮  前列环素
文章编号:1009-2501(2008)02-0149-005
修稿时间:2007-11-19

Vasodilative effect and mechanism of enalapril on thoracic aorta of rats
WANG Dan,ZHANG Xuan-ping,DONG Qiu-ju,ZHANG Ming-sheng,NIU Long-gang,CHANG Hai-liang. Vasodilative effect and mechanism of enalapril on thoracic aorta of rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(2): 149-153
Authors:WANG Dan  ZHANG Xuan-ping  DONG Qiu-ju  ZHANG Ming-sheng  NIU Long-gang  CHANG Hai-liang
Affiliation:WANG Dan, ZHANG Xuan-ping, DONG Qiu-ju, ZHANG Ming-sheng, NIU Long-gang, CHANG Hai-liang(Department of Pharmacology, Shanxi Medical University, 2Department of Cardiology, First Hospital Affiliated to Shanxi Medical University, Taiyuan 030001, Shanxi, China)
Abstract:AIM: To investigate the vasodilative effects and the possible mechanism of enalapril on thoracic aorta of rats. METHODS: Isotonic tension of thoracic aortic rings precontracted by norepinephrine (NE, 10^-5 mol/L) or KCl (20 mmol/L) was recorded. The vascular tension was recorded by Powerlab multichannel physiology signal acquisition and analysis computer system by tension transducers. The vasorelaxing action of enalapril and effects of various drugs which include NG-nitro-L-arginine methyl ester (10^-4mol/L) and indomethacin (10^-8 mol/L) were observed in the rings with endothelium intact or denuded. RFSULTS: Enalapril ( 10^-9 - 10^-4 mol/L) induced concentrationdependent relaxation in thoracic aortas with intact endothelium. There was significant difference between the rings with intact and denuded endothelium. N^G-nitro- L-arginine methyl ester ( 10^-4 mol/L) and indomethacin ( 10^-8 tool/L) can signifi effects of enalapril on thoracic SION: We conclude that cant inhibit the relaxtion aortic rings. CONCLUenalapril preferentially antagonized the contraction of rat thoracic artery in a concentration-dependent and The vasorelaxation of duction of nitric oxide and prostacyclin.
Keywords:enalapril  thoracic aorta  vasodilation  endothelium  nitric oxide  prostacyclin
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