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| 脱氧雪腐镰刀菌烯醇致家兔多脏器损伤的实验观察 | |
| 引用本文： | 李群伟,侯海峰,李亚鲁,韩纪举,王欣农,李晓梅. 脱氧雪腐镰刀菌烯醇致家兔多脏器损伤的实验观察[J]. 中国地方病防治杂志, 2007, 22(1): 19-22 |
| 作者姓名： | 李群伟 侯海峰 李亚鲁 韩纪举 王欣农 李晓梅 |
| 作者单位： | 1. 泰山医学院流行病学研究所,泰安,271016 2. 泰山医学院形态学实验室,泰安,271016 3. 泰山医学院基础医学研究所,泰安,271016 |
| 摘 要： | 目的观察脱氧雪腐镰刀菌烯醇（DON）对家兔器官的毒性及损伤作用。方法将成年雄性家兔随机分为高剂量组、低剂量组和对照组，高、低剂量组分别用0．1mg·kg^-1BW，0．05mg·kg^-1 BW剂量的脱氧雪腐镰刀菌烯醇，经耳缘静脉注射染毒，每48h染毒一次，染毒10次后处死家兔，取心、肝、肾、脾等器官进行常规病理检查。结果染毒家兔的心、肝、肾、脾均有病理变化，可见组织细胞肿胀、空泡变性、炎性细胞浸润及细胞坏死。结论DON具有明显的细胞毒性，对多脏器具有损伤作用。 |
| 关 键 词： | 脱氧雪腐镰刀菌烯醇(DON) 脏器损伤 家兔 |
| 文章编号： | 1001-1889（2007）01-0019-04 |
| 修稿时间： | 2006-10-16 |
Experimental observation of multiple organ impairment on rabbits by deoxynivalenol |
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| LI Qun - wei, HOU Hai - feng, LI Ya - lu, et al. Experimental observation of multiple organ impairment on rabbits by deoxynivalenol[J]. Chinese Journal of Control of Endemic Disenaces, 2007, 22(1): 19-22 | |
| Authors: | LI Qun - wei HOU Hai - feng LI Ya - lu et al |
| Abstract: | Objective To observe toxic effect and damaged condition of rabbit organs induced by deoxynivalenol (DON).Methods The rabbits were separated into three groups. Saline solution of DON was injected into ear vein of rabbits at every 48 h. Specimens of hearts, livers, kidneys,spleens and arteries were investigated through pathology methods after 20 days.Result Toxic effect of DON was observed, such as leukocytic infiltration, tissue swelling, vacuolation and necrosis.Conclusion DON caused cytotoxity and organ impairment. |
| Keywords: | Deoxynivalenol(DON) Organ impairment Rabbits |
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