超声引导下乳腺癌细针穿刺标本中癌胚抗原和雌激素受体检测的临床意义

目的 探讨癌胚抗原（carcinoembryonic antigen,CEA)和雌激素受体（estrogen receptor,ER)的检测在乳腺癌早期、晚期辅助诊断中的临床意义。方法 采用放射免疫技术检测118例乳腺细针穿刺标本（69例乳腺癌，49例乳腺良性病变）中的CEA。并用免疫组化技术检测69例乳腺癌穿刺标本及相应组织切片的ER表达。结果 乳腺癌与乳腺良性病变组织中的CEA活性差异有显著意义（P＜0.01)，前者明显升高。乳腺癌细针穿刺标本和组织切片中ER表达有极显著的一致性（P＜0.01)，两者一致率为90％。结论 细针穿刺取材检测其CEA水平和ER表达，有助于早、晚期乳腺癌的诊断和制定合理的治疗方案。

Clinical significance of CEA and ER detection by US-guided fine needle aspiration in patients with breast cancer

ObjectiveTo investigate the diagnostic significance of CEA and ER detection in patients with early and advanced breast cancer. Methods118 fine needle aspiration specimens from patients with breast mass (69 patients with breast cancer, and 49 patients with benign lesions) were studied for the presence of CEA activity by radioimmunoassay. 69 fine needle aspiration specimens from patients with breast cancer and their corresponding tissue sections were studied for the expression of ER by immunohistochemical method. ResultsThe activity of CEA was significantly different between the specimens of breast cancer and those of breast benign lesions ( P <0 01) and the former was significantly enhanced. The coincidence rate between fine needle aspiration detection and sectional confirmation was 89.86% ( P <0 001). ConclusionThe detection of CEA and ER in breast tissue samples abtained by US guided fine needle aspiration is helpful to the early/advanced diagnosis of breast cancer.