| CXCR4 单克隆抗体对新生血管形成的影响 |
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| 引用本文： | 马宇光,武力,王红磊.CXCR4 单克隆抗体对新生血管形成的影响[J].现代肿瘤医学,2008,16(12):2069-2071. |
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| 作者姓名： | 马宇光 武力 王红磊 |
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| 作者单位： | 兰州大学第一医院乳腺外科,甘肃,兰州,730000 |
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| 摘 要： | 目的：探讨CXC趋化因子受体4（CXCchemokinereceptor4，CXCR4）单克隆抗体（CXCR4mAb）对新生血管形成的影响及其作用机制。方法：以鸡胚绒毛尿囊膜（chorioallantoicmembrane，CAM）血管抑制实验检测CXCR4单克隆抗体对新生血管形成的影响，WesternBlot免疫印迹法检测血管内皮细胞SDF-1蛋白的表达。结果：CXCR4单克隆抗体可明显抑制新生血管的形成，并且使培养的血管内皮细胞SDF-1蛋白表达明显降低：结论：CXCR4mAb可通过SDF-1／CXCR4生物轴抑制新生血管的形成。
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| 关 键 词： | CXC趋化因子受体4单克隆抗体 新生血管形成 基质细胞衍生因子-1 |
Effect of chemokine receptor CXCR4 monoclonal antibody on angiogenesis |
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| MA Yu-guang,WU Li,WANG Hong-lei.Effect of chemokine receptor CXCR4 monoclonal antibody on angiogenesis[J].Journal of Modern Oncology,2008,16(12):2069-2071. |
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| Authors: | MA Yu-guang WU Li WANG Hong-lei |
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| Abstract: | Objective:To study the effect of CXCR4 monoclonal antibodies(CXCR4 mAb) on angiogenesis.Methods:After the addition of CXCR4 mAb,the effect of angiogenesis was observed by chorioallantoic membrane(CAM) and the expression of SDF-1 protein in cultured vascular endothelial cells was measured with Western blotting analysis.Results:As compared with CON,CXCR4 mAb inhibited angiogenesis in CAM and decreased the expression of SDF-1 in vascular endothelial cells.Conclusion:SDF-1/CXCR4 plays an important role in regulating the angiogenesis. |
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| Keywords: | CXCR4 mAb angiogenesis SDF-1 |
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