Bone repair following bone grafting hydroxyapatite guided bone regeneration and infra-red laser photobiomodulation: a histological study in a rodent model |
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Authors: | Antonio Luiz B. Pinheiro Marleny E. Martinez Gerbi Francisco de Assis Limeira Jr. Elizabeth Arruda Carneiro Ponzi Aparecida M. C. Marques Carolina Montagn Carvalho Rafael de Carneiro Santos Priscila Chagas Oliveira Manuela Nóia Luciana Maria Pedreira Ramalho |
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Affiliation: | Department of Propedeutica and Clínica Integrada, Laser Center, School of Dentistry, Federal University of Bahia, Salvador, BA, Brazil. albp@ufba.br |
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Abstract: | The aim of the investigation was to assess histologically the effect of laser photobiomodulation (LPBM) on a repair of defects surgically created in the femurs of rats. Forty-five Wistar rats were divided into four groups: group I (control); group II (LPBM); group III (hydroxyapatite guided bone regeneration; HA GBR); group IV (HA GBR LPBM). The animals in the irradiated groups were subjected to the first irradiation immediately after surgery, and it was repeated every day for 2 weeks. The animals were killed 15 days, 21 days and 30 days after surgery. When the groups irradiated with implant and membrane were compared, it was observed that the repair of the defects submitted to LPBM was also processed faster, starting from the 15th day. At the 30th day, the level of repair of the defects was similar in the irradiated groups and those not irradiated. New bone formation was seen inside the cavity, probably by the osteoconduction of the implant, and, in the irradiated groups, this new bone formation was incremental. The present preliminary data seem to suggest that LPMB therapy might have a positive effect upon early wound healing of bone defects treated with a combination of HA and GBR. |
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Keywords: | Bone regeneration Laser biomodulation Biomaterials Hydroxyapatite Membrane |
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