监测未足月胎膜早破孕妇血C反应蛋白及白细胞介素-6的意义

目的:探讨监测母血C反应蛋白(CRP)及白细胞介素-6(IL-6)对预测未足月胎膜早破(PPROM)早期绒毛膜羊膜炎(CMA)的意义。方法:收集PPROM孕妇羊水,测定沙眼衣原体IgM抗体、巨细胞病毒IgM抗体、解脲支原体,并作细菌培养;采集母血测定CRP及IL-6含量。结果:①PPROM合并早期CMA者母血CRP、IL-6含量明显升高。②母血CRP≥0.15g.L-1、IL-6≥6.12×10-8g.L-1为预测PPROM合并早期CMA的最适诊断值。结论:监测母血CRP及IL-6变化可以预测早期宫内感染。

A study of C-reactive protein and interleukin-6 in maternal serum in patients with preterm premature rupture of the membranes.

Objective:To study whether maternal serum C-reactive protein(CRP) and interleukin-6(IL-6) can predict the early chorioamnionitis(CMA) in patients with preterm premature rupture of membranes(PPROM).Methods:Amniotic fluid(AF) retrieved from women with PPROM was cultured for aerobic and anaerobic bacteria and analyzed for anti-cytomegalovirus IgM,anti-chlamydia trachomatis IgM and ureaplasma urealyticum.Maternal blood was collected for determination of CRP and IL-6.Results:①The level of maternal serum CRP and IL-6 determination raised signficantly in the detection of positive AF pathogen(P<0.05).②Maternal serum CRP≥0.15 g/L and IL-6≥6.12×10-8 g/L could be used to diagnose early CMA.Conclusion:The maternal serum CRP and IL-6 determination can be used for the prediction of early CMA conveniently.