Cox-2和P-21蛋白在子宫内膜癌中的表达及意义

目的探讨子宫内膜癌中P-21蛋白和环氧化酶-2(Cyclooxygenase-2,COX-2)的表达和意义。方法采用免疫组织化学中的SP法对对照组中20例正常的子宫内膜组织患者、非典型增生组中的7例子宫内膜出现非典型增生组织患者以及子宫内膜癌组中的55例子宫内膜癌组织患者中P-21蛋白及COX-2的表达情况进行检测。结果与非典型增生组和子宫内膜癌组相比,对照组中患者P-21蛋白的阳性表达率显著较高(P<0.05),而对照组中Cox-2的阳性表达率显著较非典型增生组和子宫内膜癌组低(P<0.05);在手术-病理分期和分化程度,以及淋巴结出现转移等宫内膜癌组织的相关方面,P-21蛋白的阳性率具有明显差异(P<0.05);Cox-2阳性率在子宫内膜癌组织的手术-病理分期、分化程度、肌层浸润方面差异有统计学意义(P<0.05),子宫内膜癌组织P-21蛋白阳性表达率与Cox-2阳性呈负相关(r=-0.498,P=0.000)。结论 P-21蛋白和Cox-2异常表达可能在子宫内膜癌的发生、发展中起重要作用。

Expression and significance of Cyclooxygenase-2 and p-21 protein in endometrial cancer

Objective To explore the expression and significance of p-21 and Cyclooxygenase-2 protein in endometrial cancer. Methods Immunohistoche mical SP method was used to detect the expressions of p-21 and Cox-2 protein in 20 cases of normal endometrium （control group ）, 9 cases of endometrial atypical hyperplasia （atypical hyperplasia group） and 57 cases of endometrial carcinoma （endometrial cancer group） Results The positive rate of p-21 protein was obviously higher in control group than that in the other group（P〈0.05）. The positive rate of Cox-2 protein in control group was obviously lower than that inthe other groups（P〈0.05）.The positive rate of p-21 protein was significantly different in operation stage ,pathology stage, differentiation degree and lymph metastasis（P〈0.05）.The positive rate of Cox-2 protein was significantly different in operation stage, pathology stage, differentiation degree and Myometrial invasion（P〈0.05）In endometrial carcinoma group, the positive rate of p-21 protein was negatively correlated with the high proliferation rate of Cox-2 （r=-0.498, P=-0.000） Conclusion The abnormal expressions of p-21 and Cox-2 protein may play an important role in carcinogenesis and development of endometrial cancer.