消氮颗粒对大鼠腺嘌呤所致慢性肾衰竭的作用

目的观察消氮颗粒对腺嘌呤所致慢性肾衰竭大鼠的作用。方法除正常对照组(10只)外,其他大鼠采用腺嘌呤建立慢性肾衰竭模型,将该模型大鼠随机分为模型对照组,消氮颗粒低、中、高剂量(0.989、1.977、3.956 g/kg·d)组和阳性对照(给予尿毒清颗粒2.088 g/kg·d)组,每组12只,分别用相应的药物灌胃治疗30 d,观察对比各组大鼠血肌酐(SCr)、尿素氮(BUN)、尿酸(UA)和电解质钾(K+)、钠(Na+)、钙(Ca2+)、磷(P3+)以及尿蛋白(PRO)、中性粒细胞(LEU)、尿比重(SG)和肾脏病理学的变化。结果与模型组比较,阳性对照组和消氮颗粒低、中、高剂量组血清SCr、BUN、UA、电解质P3+的含量显著降低,PRO、LEU、SG指标趋于正常,肾组织的功能有所改善。结论消氮颗粒对大鼠腺嘌呤所致慢性肾衰竭有改善作用。

Effects of Xiaodan granules on chronic renal function failure rats induced by adenine

Objective To observe the effects of Xiaodan granules on renal function of rats with chronic renal failure（CRF）induced by adenine. Methods Except for the normal control（n=10）,the rats with CRF induced by adenine were randomly divivded into five groups：model,low,middle,high-dosage（0.989,1.977,3.956 g / kg·d） of Xiaodan granules and positive control group with Niaoduqing granules（2.088 g / kg·d）,n =12,for each group.Corresponding drugs were given to these five groups for 30 days,The serum creatinine（SCr）,blood urea nitrogen（BUN）,uric acid（UA）,and electrolyte K＋,Na＋,Ca2 ＋,P3 ＋,as well as proteinuria（PRO）,neutrophils（LEU）,urine specific gravity（SG）,and renal pathology were observed and compared each other to find out differences among them. Results Compared with the model group,SCr,BUN,UA and P3 ＋of other 5 groups were significantly decreased,and the index of PRO,LEU,SG tended to be normal. Conclusion Xiaodan granules have definitely therapeutic effect on chronic renal failure of rats caused by adenine.