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Application of solid-phase extraction to the isolation and determination of paracetamol and its metabolites |
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| Authors: | M el Mouelhi B Buszewski |
| Affiliation: | a Institute of Toxicology, University of Tübingen, D-7400 Tübingen, FRG b Institute of Organic Chemistry, University of Tübingen, D-7400 Tübingen, FRG |
| Abstract: | A series of clean-up columns for solid-phase extraction (SPE) were packed with various C18 phases of different physico-chemical surface properties. These SPE columns were used for the isolation and determination of paracetamol and its metabolites from biological samples. The packing with a monomeric structure of chemically bonded phase showed the best recovery of tested substances in urine. |
| Keywords: | Solid-phase extraction chemically bonded phase acetaminophenoles glucuronide and glutathione-derived conjugates |
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