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| 诱生型一氧化氮合酶在白色和杂色豚鼠脉冲噪声损伤耳蜗中的表达 | |
| 引用本文： | 何青莲,熊敏,李云英,石灵春,谭敏,李华. 诱生型一氧化氮合酶在白色和杂色豚鼠脉冲噪声损伤耳蜗中的表达[J]. 广州中医药大学学报, 2010, 27(1): 87-89,101 |
| 作者姓名： | 何青莲 熊敏 李云英 石灵春 谭敏 李华 |
| 作者单位： | 1. 广州中医药大学第二临床医学院病理科,广东,广州,510120 2. 广州军区广州总医院耳鼻咽喉科,广东,广州,510010 3. 广州中医药大学第二临床医学院耳鼻咽喉科,广东,广州,510120 |
| 基金项目： | 广东省卫生厅医学科研基金资助项目 |
| 摘 要： | 【目的】观察诱生型一氧化氯合酶（iNOS）在脉冲噪声暴露白色和杂色豚鼠耳蜗中的表达，以探讨黑色素对耳蜗损伤的保护作用机理。【方法】将白色和杂色豚鼠暴露于脉冲噪声，复制耳蜗损伤的模型。采用免疫组织化学的方法观察iNOS在两组豚鼠耳蜗中的表达。【结果】iNOS在两组脉冲噪声暴露豚鼠耳蜗中均呈阳性表达，以血管纹和螺旋神经节的表达较强，而且iNOS在白色豚鼠耳蜗的表达显著强于杂色豚鼠。【结论】耳蜗黑色素拮抗耳蜗损伤的作用可能是通过抑制耳蜗iNOS表达来实现的。 |
| 关 键 词： | 耳蜗／损伤 耳蜗／病理学 脉冲噪声 黑色素 疾病模型，动物 豚鼠 |
Expression of Inducible Nitric Oxide Synthase in Cochlea of White and Pigmented Guinea Pigs Exposed to Impulsive Noise |
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| HE Qinglian,XIONG Min,LI Yunying,SHI Lingchun,TAN Min,LI Hua. Expression of Inducible Nitric Oxide Synthase in Cochlea of White and Pigmented Guinea Pigs Exposed to Impulsive Noise[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2010, 27(1): 87-89,101 | |
| Authors: | HE Qinglian XIONG Min LI Yunying SHI Lingchun TAN Min LI Hua |
| Affiliation: | HE Qinglian1,XIONG Min2,LI Yunying3,SHI Lingchun1,TAN Min1,LI Hua3 (1.Dept.of Pathology,the Second School of Clinical Medicine,Guangzhou University of TCM,Guangzhou 510120 Guangdong,China,2.Dept.of Otorhinolaryngology,Guangzhou General Hospital of Guangzhou Military Comm, of Chinese PLA,Guangzhou 510010 Guangdong,3.Dept.of Otorhinolaryngology,China) |
| Abstract: | Objective The expression of inducible nitric oxide synthase(iNOS) was investigated in the cochlea of white and pigmented guinea pigs exposed to impulsive noise to explore the contribution of melanin in protecting cochlea from damage.Methods Both white and pigmented guinea pigs were exposed to the impulsive noise to establish the animal model of cochlea injury.The expression of iNOS in the cochlea was examined by the method of immunohistochemistry.Results There showed a positive expression of iNOS in the coc... |
| Keywords: | COCHLEA/injuries COCHLEA/pathology IMPULSIVE NOISE MELANIN DISEASE MODELS ANIMAL GUINEA PIGS |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |