肺炎衣原体抗体效价与多发性硬化的相关性探讨

目的 探讨肺炎衣原体（Chlamydia pneumoniae）感染在多发性硬化（MS）发病和进展中的作用和致病机制。方法 选取急性期MS患者31例，缓解期MS患者28例及其他神经系统疾病患者30例，健康对照者30名，应用酶联免疫吸附试验测定患者和对照者血清及脑脊液中肺炎衣原体IgG和IgM抗体水平。结果 急性期MS组、缓解期MS组、其他神经系统疾病组和健康对照组的肺炎衣原体血清IgG分别为48．4％、35．7％、30．0％、23．3％；4组IgM抗体效价分别为12．9％、14．3％、20．0％、10．0％，总体比较差异无统计学意义（P〉0．05）；急性期MS组与其他神经系统疾病组的脑脊液IgG和IgM抗体效价分别为0、6．7％和0、0，差异无统计学意义（P〉0．05）。结论 肺炎衣原体的感染或重复感染与MS发病相关不紧密，可能仅为MS的伴随感染。

Correlation between antibody titer of Chlamydia pneumoniae and pathogenesis of multiple sclerosis

Objective To investigate the correlation between Chlamydia pneumoniae infection and multiple sclerosis (MS) and to explore the pathogenesis of the pathogen. Methods In this study,31 patients with relapsing MS (RPMS),28 patients with remitting MS (RMMS), 30 patients with other neurologic diseases (OND) and 30 healthy persons (HEA) were tested serologically for specific Chlamydia pneumoniae IgG and IgM antibodies with ELISA. CSF was tested for IgG and IgM in RPMS and OND,too. Results The Chlamydia pneumoniae IgG seropositivity in RPMS,RMMS,OND and HEA was 48.4%, 35.7%,30.0% and 23.3% respectively,and there was no significant difference (P>0.05) in 4 groups. The Chlamydia pneumoniae IgM seropositivity of 4 groups was 12.9%, 14.3%, 20.0% and 10.0% respectively,and there was no significant difference (P>0.05) in 4 groups too. Besides the serumal antibodies,the positive rate of Chlamydia pneumoniae IgG and IgM in RPMS and OND patients was 0, 6.7% and 0,0 respectively. The difference was not significant (P>0.05). Conclusions Our study does not support a positive association between Chlamydia pneumoniae infection or reinfection and MS. Chlamydia pneumoniae may be a bystander pathogen.