| nm23、p53和bcl-2 蛋白的表达与鼻咽癌生物学行为及预后的关系 |
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| 引用本文： | 何常,薄丽,钟愉. nm23、p53和bcl-2 蛋白的表达与鼻咽癌生物学行为及预后的关系[J]. 贵州医药, 2004, 28(1): 22-23 |
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| 作者姓名： | 何常 薄丽 钟愉 |
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| 作者单位： | 贵阳医学院病理学教研室,550004;贵阳医学院病理学教研室,550004;贵阳医学院病理学教研室,550004 |
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| 基金项目： | 贵州省科委基金资助项目(E97-3) |
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| 摘 要： | 目的研究nm23、p53和bcl-2蛋白的表达与鼻咽癌(NPC)生物学行为及预后的关系.方法应用免疫组织化学SP法检测64例NPC组织中nm23、p53和bcl-2蛋白的表达.结果64例NPC中nm23、p53和bcl-2蛋白的阳性表达率分别为54.7%(35/64)、29.7%(19/64)、81.3%(52/64),nm23、p53和bcl-2蛋白表达均与NPC的淋巴结转移和预后有关(P＜0.05～0.005),与TNM分期无关(P＞0.05).结论nm23、p53和bcl-2蛋白的表达参与了NPC的发生、发展并影响其预后.
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| 关 键 词： | 鼻咽肿瘤 nm23蛋白 p53蛋白 bcl-2蛋白 预后 |
The relationship between nm23, p53, bcl-2 expression and prognosis in nasopharyngeal carcinomas |
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| He Chang,Bo Li,Zhang Yu. The relationship between nm23, p53, bcl-2 expression and prognosis in nasopharyngeal carcinomas[J]. Guizhou Medical Journal, 2004, 28(1): 22-23 |
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| Authors: | He Chang Bo Li Zhang Yu |
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| Affiliation: | He Chang,Bo Li,Zhang Yu. Department of pathology,Guiyang Medical College,Guiyang550004 |
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| Abstract: | Objective To study the relationship between the expression of nm23, p53, bcl-2 and prognosis in nasopharyngeal carcinoma(NPC). Methods The expression of nm23, p53, bcl-2 protein in 64 cases NPC were studied by immunohistochemistry of SP. Results The positively rates of nm23, p53,bcl-2 were related to the lymph node metastasis and prognosis in NPC(P<0. 005~0. 05). Conclusion The nm23, p53,bcl-2 were involved in the tumorigenesis, development and prognosis in NPC. |
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| Keywords: | NPC nm23 protien p53 protien bcl-2 protien Prognosis |
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