乙肝后肝硬变患者血浆内源性一氧化氮水平及其意义

目的探讨乙肝肝硬变患者血浆内源性一氧化氮（ＮＯ）水平及其与腹水的关系．方法测定３４名无腹水（Ａ组）、５１名有腹水（Ｂ组）的乙肝肝硬变患者及５０名健康献血员血浆内源性一氧化氮及内毒素水平，结果以ｔ检验、ｘ２检验作统计学分析。结果Ａ．Ｂ组血浆ＮＯ及内毒素水平均较献血贝明显升高（Ａ组Ｐ＜０．０５，Ｂ组Ｐ＜０．０１），Ｂ组者较Ａ组者升高显著（Ｐ＜０．０５），Ｂ组内毒素血症发生率较Ａ组高（Ｐ＜０．０５）．患者血浆内源性ＮＯ水平与内毒素水平正相关（ｒ＝０．５２８，Ｐ＜０．００１）．结论乙肝肝硬变患者腹水可能与内源性ＮＯ有关，降低血浆内源性ＮＯ水平对这些患者可能有益．

Signincance of cndogcnous nitric oxide in Patients with post-hepatitis B cirrhosis of liver

Objective To reseach the relationship between ascites and the levels of plasma endogenous nitric oxide (NO) in patients with post-hepatitis B cirrhosis of liver. Methods Eight-five cases with post-hepatitis B cirrhosis of liver and 50 blood donors were studied. The levels of plasma endogenous NO and endotoxin were measured in 34 patients without ascites (group A), 51 patients with ascites (group B) and 50 donors.The ttest and Chi-square test were used for statistical analysis.Results Both the levels of plasma endogenous NO and endotoxin were significantly increased in patients than that in donors (P<0. 05 for group A and P<0.01 for group B, respectively), and was significafly increased in group B than that in group A (P<0.05) .The incidence of endotoxemia in group B was significantly higher than that in group A (P<0.05).Conclusion Ascites may be related to plasma endogenous NO in the patients with post-hepatitis B cirrhosis of liver. It may be beneficial for the patients to reduce the levels of plasma endogenous NO.