| 去纤酶对高血脂兔血小板功能、纤溶系统、血液流变学的影响 |
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| 引用本文： | 唐亚辉,李茨芬.去纤酶对高血脂兔血小板功能、纤溶系统、血液流变学的影响[J].海军总医院学报,1994(4). |
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| 作者姓名： | 唐亚辉 李茨芬 |
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| 作者单位： | 海军总医院血液实验室(唐亚辉)，解放军总医院血液室(李茨芬) |
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| 摘 要： | 观察了食饵性高血脂对新西兰兔血小板功能、纤溶系统和血液流变学的影响以及去纤酶的调节作用,并动态观察了指标的变化.结果发现,高血脂能引起兔的血小板数增加,粘附力增强,血液粘滞性增加,红细胞流动变慢,呈现高凝和低纤溶状态,且主动脉形成明显粥样斑块.去纤酶在降低血脂的同时,可明显降低血小板的粘附力,降低血液粘滞性,呈现低凝和高纤溶状态,其主动脉粥样斑块亦明显减轻和缩小.提示去纤酶既能降低血脂又能降低血粘稠度,促进纤溶,起到抗凝及防止血栓形成,抑制动脉硬化的形成和发展.
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| 关 键 词： | 去纤酶 高血脂 血小板 纤溶功能 血液流变学 |
The effects of defibrase in platelet function fibrinolytic activity and rheology in rabbits with high cholesterol diet. |
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| Tang Yahui et al.The effects of defibrase in platelet function fibrinolytic activity and rheology in rabbits with high cholesterol diet.[J].Journal of Naval General Hospital of PLA,1994(4). |
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| Authors: | Tang Yahui |
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| Institution: | Tang Yahui et al |
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| Abstract: | Defibrase purified from the venom of agkistrodon acutus is being widely used in thetreatmeat of vascular thrombotic diseases ,but there has been no report of using defibrase for the prevention of atherosclerosis. The present study is to investigate the effect of defibrase for the preventionof atherosclerosis in rabbits . In conclusion ,intravenous injection of defibrase can reduce TC,inbibite platelet function, increase plasma fibrinolytic activity and reduce blood viscosity. Through thesechanges ,atherosclerosis can be prevented to some extent by using defibrase. |
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| Keywords: | Defibrase Hyperlipoidemia Platelet Fibri-nolytic function Blood rheology |
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