Effect of intracellular anisotropy on electrical source determination in a muscle fibre |
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Authors: | R Plonsey |
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Institution: | (1) Department of Biomedical Engineering, Cell Biology, Duke University, 27706 Durham, NC, USA |
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Abstract: | Expressions are available for describing, quantitatively, the source associated with an action potential propagating along
an excitatble fibre. For a nerve fibre one such expression defines an equivalent volume dipole density function τ(x) = − ∂/∂x
(σi φi(x) − σe φe(x))ax (where x is the axial co-ordinate, i is the intracellular and e the extracellular region, σi and σe are isotropic conductivities, ϕ the potential at the membrane, while axial symmetry is assumed), and this source fills the
intracellular region. This source, as distinct from transmembrane current formulations, lies in a uniform, isotropic, extracellular,
medium. Consequently, for a fibre bundle a simple superposition of sources, all lying in a uniform, isotropic, extracellular
space, can be accomplished. However, for muscle fibres the presence of non-conducting myofibrils causes the intracellular
space to be anisotropic. The paper describes the modification in the aforementioned expressions for the case of longitudinal
and transverse propagation and extrapolation to an arbitrary angle of propagation. The resultant source continues to be expressed
relative to a uniform, isotropic, extracellular medium. |
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Keywords: | Action potentials Anisotropic Electrical source Muscle fibres Myofibrils |
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