Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia |
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| Authors: | Miyazaki Ikuko Asanuma Masato Diaz-Corrales Francisco J Miyoshi Ko Ogawa Norio |
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| Affiliation: | Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikatacho, Okayama 700-8558, Japan. |
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| Abstract: | Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases. |
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| Keywords: | Neurotransmitters modulators transporters and receptors Catecholamine receptors |
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