胰高血糖素样肽-2对放射损伤小鼠小肠功能恢复的影响

放射性直肠炎是盆腔放射治疗的患者常见的并发症之一 ,为了减轻放射所致的肠损伤 ,提高病人的生活质量 ,笔者半随机分组观察了 79例患者用自制的中药灌肠剂“直肠炎一号”预防放射性直肠炎 ,现将其近期疗效报道如下。一、材料和方法1 一般资料 :2 0 0 0年 5月～ 2 0 0 0年 12月共收治可评价的接受盆腔放疗的患者 79例 ,半随机分为门诊对照组 42例 ,男 9例、女 33例 ,年龄 32～ 70岁 ,平均 5 1 5岁 ,和住院治疗组 37例 ,男 6例、女 31例 ,年龄 31～ 72岁 ,平均 5 3岁 ,其中门诊对照组中宫颈癌为 33例 ,其他为 9例 ,而住院治疗组中宫颈癌 30例…

Effect of glucagon-like peptide 2 on recovery of intestinal function from radiation injury in mice

Objective To investigate the effect of glucagon-like peptide 2(GLP-2) on recovery of intestinal epithelial function from radiation injury in mice. Methods Kunming mice received a single dose of 8 Gy total-body irradiation from ^{60 Co gamma-rays followed by treatment with GLP-2 or vehicle.Intestinal permeability,plasma endotoxin content,glucose absorption,and sucrase and lactase activities were measured on days 1,3,5 after treatment. Results In irradiated mice intestinal permeability and glucose absorption were significantly higher, and sucrase and lactase activities lower than those in normal mice on days 1,3,5(P<0^01 or P<005).Plasma endotoxin content in irradiated mice on days 1,3 was significantly higher than that in the normal mice (P<0.01 or P<0.05).In GLP-2-treated mice,intestinal permeability,glucose absorption,and plasma endotoxin content restored to normal on day 3 sucrase and lactase activities restored to normal on day 5. Conclusion GLP-2 can promote recovery of intestinal mucosal barrier function,digestion and absorption function from radiation injury.}