| 纳洛酮联合血必净治疗感染性休克的临床疗效及作用机制研究 |
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| 引用本文： | 邢正云,冯国安. 纳洛酮联合血必净治疗感染性休克的临床疗效及作用机制研究[J]. 临床急诊杂志, 2011, 12(6): 388-390 |
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| 作者姓名： | 邢正云 冯国安 |
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| 作者单位： | 1. 大丰市人民医院ICU 江苏大丰,224100
2. 大丰市人民医院血液科 |
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| 摘 要： | 目的:观察纳洛酮联合血必净治疗感染性休克的临床疗效,并探讨其可能的作用机制.方法:对45例感染性休克患者,随机分为2组,治疗组23例,对照组22例,治疗组患者在常规抗休克治疗的基础上加用纳洛酮联合血必净治疗.结果:治疗组总有效率为91.3％,明显好于对照组72. 7％(P＜0.05),监测血液动力学变化△CVP、△MAP、△UA、△ScvO2治疗组明显好于对照组(P＜0.05).治疗组MODS的发生率为30.4％(7/23).病死率为13.0％(3/23),对照组MODS的发生率为54.6％(12/22),病死率为27.3％(6/22),两组MODS的发生率比较差异有统计学意义(P＜0.05).结论:纳洛酮联合血必净能够显著改善感染性休克患者的病情,提高生存率.作用机制可能与纳洛酮能拮抗β内啡肽,血必净能降低内毒素的水平有关.
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| 关 键 词： | 感染性休克 纳洛酮 血必净 |
Clinical effects of naloxone hydrochloride combined with xuebijing on septic shock |
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| XING Zhengyun , FENG Guoan. Clinical effects of naloxone hydrochloride combined with xuebijing on septic shock[J]. Journal of Clinical Emergency Call, 2011, 12(6): 388-390 |
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| Authors: | XING Zhengyun FENG Guoan |
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| Affiliation: | XING Zhengyun1 FENG Guoan2(1Department of ICU,Dafeng people Hospital,Jiangsu,224100,China,2Department of Hematology,Dafeng people Hospital) |
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| Abstract: | Objective:To observe the clinical therapeutic effects of Naloxone Hydrochloride for Injection Combined with Xuebijing on septic shock.Method:45 cases of septic shock were randomly into therapeutic group(23 cases) and control group(22 cases) . The therapeutic group was treated with naloxone hydrochloride and Xuebijing. Control group only received basic therapy.Result:The overall response rates were 91.3% in therapeutic group and 72.7% in control group(P<0.05) . The hemodynamic variety CVP,MAP,UA,ScvO2,MODS o... |
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| Keywords: | septic shock Naloxone Hydrochloride for Injection Xuebijing |
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