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肝胆管结石并狭窄时的胆管壁组织构筑变化及意义
引用本文:夏先明,雷正明,张陪明,刘广益,谢华福,蒋灵芝. 肝胆管结石并狭窄时的胆管壁组织构筑变化及意义[J]. 中国普外基础与临床杂志, 1996, 0(3)
作者姓名:夏先明  雷正明  张陪明  刘广益  谢华福  蒋灵芝
作者单位:泸州医学院附院肝胆研究室,泸州医学院附院肝胆研究室,四川省第五人民医院,泸州医学院组织胚胎学教研室,泸州医学院组织胚胎学教研室,泸州医学院电镜室 泸州646000,泸州646000
摘    要:对21例择期手术,行定位取材获得5例左右肝管汇合部狭窄、7例I级肝管狭窄、7例Ⅱ级肝管汇合部狭窄、10例Ⅱ级肝管狭窄及10例Ⅲ级肝管汇合部狭窄标本进行连续组织学观察,并对其弹性纤维和胶原纤维进行定量分析。结果:①狭窄胆管的上皮完整,上皮细胞增生,线粒体脱颗粒、断嵴,内质网扩张,提示狭窄胆管上皮细胞的功能有障碍;②狭窄胆管及周围组织粘液腺大量增生,在腺体破坏区有局部纤维化,并可参与胆管壁纤维化;③在各部位狭窄胆管壁组织中,可见部分弹性纤维断裂,排列紊乱,使狭窄胆管壁的应变能力减弱;④狭窄胆管胶原纤维排列紊乱,可见玻璃样变性,其体积密度较正常胆管相应部位增大。

关 键 词:肝胆管狭窄  组织学  弹性纤维  胶原纤维  定量

STUDY OF THE STRUCTURE OF HEPATOBILIARY DUCT STONES WITH STRICTURE AND ITS SIGNIFICANCE
Xia Xianming,Zhang Peiming,Liu Guangyi,et al.. STUDY OF THE STRUCTURE OF HEPATOBILIARY DUCT STONES WITH STRICTURE AND ITS SIGNIFICANCE[J]. Chinese Journal of Bases and Clinics In General Surgery, 1996, 0(3)
Authors:Xia Xianming  Zhang Peiming  Liu Guangyi  et al.
Affiliation:Xia Xianming,Zhang Peiming,Liu Guangyi,et al. Department of Hepatobiliary Surgery,The First Affiliated Hospital,Luzhou Medical College,Luzhou 646000
Abstract:The structure of 39 specimens of hepatobiliary duct stones with strictures were studied histologically. The elastic and collagenous fibers were studied by quantitative analysis. The results show that the epithelium of the sttnotic bile duct are intact but with proliferation. The mitochondrions are degenerated and broken, the endoplasmic reticulum are dilated, suggesting the functional impediment of these epithelium. The mucous glands are markedly proliferated fibrosis are found near the glands which are destroyed. Some of the elastic fibers are destroyed and arranged disorderly. Hyaline degeneration was observed in collagenous fibers with remarkable increase of the volume density.
Keywords:Bile duct stricture Histology Elastic fibers Collagenous fibers Quantity
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