绿茶提取物EGCG对牙本质抗酸蚀作用的初步研究

目的观察绿茶提取物表没食子儿茶素没食子酸酯(EGCG)对牙本质抗酸蚀作用的影响。方法选取酸蚀症志愿者40名,随机分成2组。制作个别托盘,对照组托盘内注入羧甲基纤维素凝胶(CMC),实验组注入添加了EGCG的CMC凝胶,于夜间睡时佩戴,清晨取下。实验当天及第4周收集培养液,用放射免疫试剂盒测量Ⅰ型胶原羧基端肽(ICTP)的含量。结果凝胶种类对ICTP的含量均有影响,EGCG能有效降低ICTP的表达水平(P<0.05)。结论 EGCG能有效减少脱矿牙本质胶原的降解,提高牙本质抗酸蚀的能力。

Pilot study of anti erosive effect of green tea extractive EGCG on dentine

Objective It is to observe the influence of green tea extractive EGCG on anti-erosive effect of dentine.Methods Forty volunteers with dental erosion were randomly divided into two groups.The custom fitted trays were made from the heat curable braces and were injected with carboxymethyl cellulose sodium(CMC) hydrogel in one group or CMC hydrogel with EGCG added in another.These trays were used during sleep and removed from oral cavity in the next morning.The content of Carboxy-terminal telopeptide of type I collagen(ICTP) were determined by radioimmunoassay kit at 0-day and 4-week.Results The types showed significant effects on ICTP.EGCG resulted in significant decrease in the expression level of ICTP(P<0.05).Conclusion EGCG can inhibit collagen degradation and improve the anti-erosive effect of dentine.