| Sirtuin1功能及调控研究进展 |
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| 引用本文： | 赵雯,李方晖,肖冰.Sirtuin1功能及调控研究进展[J].现代预防医学,2012,39(2):378-382. |
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| 作者姓名： | 赵雯 李方晖 肖冰 |
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| 作者单位： | 1. 广州体育职业技术学院,广州,510650
2. 华南师范大学激光运动医学实验室和民族健康与体质研究中心 |
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| 摘 要： | Sirtuin1(SIRT1)是依赖于烟酰胺腺嘌呤二核苷酸辅酶(nicotinamide adenine dinucleotide,NAD+)的去乙酰化酶(Sirtuins,SIRTs)家族7个成员中最大的一个,是近年来研究最为广泛的长寿因子。SIRT1除了对组蛋白赖氨酸残基去乙酰化修饰调节表观遗传外,SIRT1还可以调节细胞其他关键蛋白活性,控制细胞增殖、分化和细胞凋亡等生理功能。最近研究发现,SIRT1调控细胞功能除了与其酶活性水平有关,也可能与其在细胞中的定位有关。SIRT1在细胞核质之间穿梭和SIRT1活性水平及其相对应的生理功能仍需深入研究.
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| 关 键 词： | Sirtuin1 生理功能 亚细胞定位 |
PROGRESS IN FUNCTIONS AND REGULATION OF SIRTUIN 1 |
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| ZHAO Wen
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LI Fang-hui
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XI-AO Bin.PROGRESS IN FUNCTIONS AND REGULATION OF SIRTUIN 1[J].Modern Preventive Medicine,2012,39(2):378-382. |
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| Authors: | ZHAO Wen LI Fang-hui XI-AO Bin |
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| Institution: | ZHAO Wen,LI Fang-hui,XIAO Bin.(Laboratory of Laser Sports Medicine and Research Center of National Constitution and Health,South China Normal University,Guangzhou 510006,China) |
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| Abstract: | Sirtuin 1(SIRT1)is the largest among the seven members of the sirtuin family of class Ⅲ nicotinamide adenine dinucleotide(NAD(+))-dependent protein deacetylases,which is the most widely studied longevity factor in recent studies.In addition to achieve the epigenetic regulation by the acetylation of lysine residues in histones,SIRT1 can also regulate the activity of several other key cellular proteins,which have emerged as critical regulators of cell growth,differentiation,and apoptotic programs.Recent studies have found that SIRT1 regulation on cell functions is not only through the level of its activity,but also through subcellular localization.SIRT1 shuttles between nucleus and cytoplasm and the level of SIRT1 activity and its physiological function regulation still need to be further studied. |
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| Keywords: | Sirtuin 1 Physiological function Subcellular localization |
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