急性脑卒中后首次随机血糖、CRP、FIB与卒中相关性研究

目的]观察急性缺血性脑卒中患者首次随机血糖、C反应蛋白(CRP)、纤维蛋白原(Fib)水平变化,并探讨其与急性脑梗塞患者中的作用及脑梗塞面积相关性,并评价其临床意义。方法]把80例急性缺血性脑卒中患者作为脑卒中组,并根据发病3d内做CT/MRI测量梗塞灶的最大直径,又把患者分为二组:①大面积梗死组(梗死灶直径≥4cm)26例,②非大面积梗死组(梗死灶直径﹤4cm)54例,同时设定对照组80例。分别测定其首次随机血糖、C反应蛋白(CRP)、纤维蛋白原(Fib)水平。结果](1)脑卒中组血糖、CRP和Fib水平明显高于对照组(P﹤0.01);(2)大面积梗死组与非大面积梗死组CRP、Fib与随机血糖水比较差异有统计学意义(前两者P﹤0.01,后者P﹤0.05)。结论]血糖、CRP、Fib水平在急性缺血性脑卒中患者中明显增高,且CRP和Fib的增高程度与病情严重程度相关,证实血糖、CRP、Fib是急性缺血性脑卒中临床事件的独立危险因素,对临床评估缺血性脑卒中危险及梗死面积有一定意义。

RESEARCH ON CORRELATION OF RANDOM BLOOD GLUCOSE,CRP,FIB AFTER THE FIRST ACUTE STROKE AND STROKE

Objective]To investigate the levels of first random blood glucose,C-reactive protein(CRP),fibrinogen(Fib)of patients with acute ischemic stroke and to explore its role in acute cerebral infarction and the relevance with area of cerebral infarction and evaluate its clinical significance.Methods]80 patients with acute ischemic stroke were as a stroke group,and based on the maximum diameter of infarct within 3 days by CT/MRI measurement,patients were divided into two groups again.The first group had large area of infarction(infarct diameter ≥ 4cm)with 26 patients and the second group had non-large area of infarction(infarct diameter﹤4cm)with 54 patients and set the control group with 80 cases.The first time random blood glucose,serum C-reactive protein(CRP)and fibrinogen(Fib)levels were determined.Results](1)Blood glucose,CPR and Fib levels in the stroke group were significantly higher than in the control group(P﹤0.01);(2)The differences of CRP,Fib and random blood glucose in the large area of infarction and non-large infarction were significant(the former P﹤0.01,the latter P﹤0.05).Conclusion]Blood glucose,CRP,Fib levels in patients with acute ischemic stroke significantly increase,and the increases of CRP and Fib levels associate with disease severity.It confirms that blood glucose,CRP,Fib are independent risk factors for acute ischemic stroke,which has the significance in clinical evaluation of the risk of ischemic stroke and the infarct size.